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Discussion We report a large-scale GWAS of treatment response to GLP1 medications and identify a missense variant in GLP1R , which encodes the therapeutic target of semaglutide and tirzepatide that associates with BMI loss
As a physician-scientist, he applies his expertise in molecular pathology, biology, genomics, and technology development to advance treatments for patients
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The main cons are that Retatrutide is not yet approved for clinical use, gastrointestinal side effects are common during the first 8 to 12 weeks, a new safety signal called dysesthesia emerged in Phase 3, long-term data beyond 68 weeks is still limited, and weight tends to return after discontinuing treatment
