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(Contraindications) Sermorelin is contraindicated in individuals with: Known allergy to Sermorelin acetate or its components.19 Pregnancy (Category C 13) or breastfeeding.7 Active malignancy (cancer), due to GH's cell proliferation potential.6 Untreated hypothyroidism, as it can blunt Sermorelin's effects.6 Acute critical illness.39 Certain pituitary conditions (e.g., GHD secondary to intracranial lesions were not studied in some key trials 13)
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Blood pressure medications, diuretics, and SGLT2 inhibitors may require dose adjustment as weight loss and improved insulin sensitivity occur
To assess this, randomized trials typically evaluate the primary outcome of major adverse cardiovascular events (MACE), which includes cardiovascular death, non-fatal stroke, and non-fatal myocardial infarction (MI)
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