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Quercetin also reduces neuronal apoptosis by inhibiting MAPK signaling and restoring PI3K/Akt pathway (Grewal et al., 2021)

Downregulation of selenoprotein mRNAs including GPX3 97 , GPX1 , and GPX4 96,98 , and Selenop 99 was observed in human and mouse OA chondrocytes

doi: 10.1096/fj.202001807 56 De PasqualeV.QuiccioneM

[8] Patients with significant alcohol intake or thiamine deficiency also require precaution: chronic heavy alcohol use can deplete thiamine (vitamin B) and taking ALA in the setting of thiamine deficiency has been associated with serious health risks (including a condition resembling Wernickes encephalopathy)