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This pattern is typical for GLP-1 class medications and suggests the 72-week data represents near-maximum efficacy for most patients
28 Orforglipron demonstrated over 12% weight loss in a 72-week Phase III study, positioning it as a potent alternative to weekly injections
Long-Term Considerations: Weight Regain and Metabolic Health Weight regain represents a significant concern when patients discontinue tirzepatide or other GLP-1 medications
The downstream benefits like muscle recovery, body composition, and sleep improvement are less robustly proven in healthy adults
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