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Symptoms of folate deficiency Some of the symptoms that can be caused by a lack of folate include: General symptoms Fatigue Irritability Headache Dizziness Gastrointestinal symptoms Sore tongue Mouth ulcers Diarrhea Loss of appetite Neurological symptoms Numbness and tingling in the hands and feet Confusion Depression Cognitive impairment Dementia Hematological symptoms Anemia (pale skin, shortness of breath) Testing for vitamin B12 and folate deficiency When to test Since vitamin B12 and folate affect many functions in the body and there are many possible symptoms, blood testing for vitamin B12 and folate is commonly ordered by the physicians at the Adult Down Syndrome Center

Sixteen weeks of GlyNAC supplementation in older adults significantly restored mitochondrial function, increased gait speed by 19%, improved physical function, and decreased oxidative stress (TBARS) by 80% and inflammation markers

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Additionally, analysis of the rate of gastric emptying can be instrumental to assess for satiety-promoting drug effects at the level of the gut