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Tirzepatide is a dual GLP-1 and GIP receptor agonist that works by targeting hunger pathways in the brain and improving blood sugar control
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Certain atypical antipsychotics as adjunctive treatment in MDD, such as olanzapine and quetiapine, are also associated with metabolic adverse effects and drug-induced weight gain [150, 151]
Physiological BCAA concentrations support anabolic processes and cellular repair, whereas chronic pathological elevation is associated with mTORC1 hyperactivation alongside impaired BCKDH-mediated catabolic flux, accumulation of branched-chain -keto acids (BCKAs) and branched-chain acylcarnitines, mitochondrial redox imbalance, and activation of cellular stress pathwayscollectively contributing to disrupted metabolic homeostasis, amplified inflammatory cascades, and mitochondrial dysfunction
