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However, IL-17 neutralization during ongoing CS exposure partially restores lung mechanics (113), indicating that an intervention window persists while active inflammation continues to drive tissue destruction
Determination of baseline human nasal pH and the effect of intranasally administered buffers
proposed the notion of a stable two-cell system between macrophages and fibroblasts, where fibroblasts secrete colony stimulating factor 1 (CSF-1), essential for the survival of macrophages, and in turn macrophages produce platelet-derived growth factor (PDGF) that is key in promoting the proliferation and maintenance of fibroblast populations (38, 39)
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