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Melanocytes also act as neuroendocrine cells producing local neurotransmitters including acetylcholine, catecholamines and opioids, and hormones of the melanocortin system such as proopiomelanocortin, adrenocorticotropic hormone and -melanocyte stimulating hormone, that participate in intracellular and in intercellular signalling pathways, thus contributing to tissue homeostasis

In fact, there is a significant inverse linear correlation between riboflavin intake and MDA, a lipid peroxide, as found in a Moscow-based cross-sectional study (33)

Proper dose titration