JARID1B regulates CDX2 expression by demethylation of H3K4me3 , which inhibits upstream methylation and promotes cell proliferation in CRC through the Wnt/beta-catenin pathway (Huang et al., 2020)
The most important serious side effects include acute pancreatitis (severe persistent abdominal pain radiating to the back, though clinical trials found similar pancreatitis rates to comparators), severe dehydration from persistent vomiting or diarrhea (signs include dizziness, decreased urination, extreme thirst), gallbladder disease including cholecystitis or cholelithiasis (right upper quadrant pain, fever, jaundice), severe allergic reactions (difficulty breathing, swelling of face or throat), and severe hypoglycemia when combined with insulin or sulfonylureas (confusion, loss of consciousness, seizures)
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Most acute injuries show significant resolution