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There is only the case of the nuclear transcription factor c-Jun that, due to an unusual redox potential, could react with GSSG at relatively high ratio of GSH/GSSG = 13 (Klatt et al., 1999)
Glutathione is not just a lone ranger
Given the central role of ROS homeostasis in health and disease, targeting ROS and their mediated ROS balancing pathways holds great therapeutic potential [556, 557]
In this study, they found that both miR-148a and miR-152 are downregulated in BC cell lines due to DNA hypermethylation as compared to normal breast cells
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