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Escitalopram reaches peak plasma concentration approximately 5 hours after a single oral dose, per FDA pharmacokinetic data
In the context of DR, this leads to the phosphorylation of ERK1/2, increasing downstream expression of anti-apoptotic genes like BCL2 and reducing the activity of pro-apoptotic markers such as Caspase-3
Weight loss medications may not be appropriate for everyone and can cause serious side effects
This last point is legally significant because it undermines the argument that the vision loss is caused by underlying diabetes rather than the medication itself
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