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POTS and Orthostatic Intolerance: By facilitating the livers clearance of circulating histamine, glutathione reduces inappropriate vasodilation and blood pooling, helping to stabilize blood pressure and reduce the compensatory rapid heart rate associated with dysautonomia

First, several of these compounds are promoted for their effects on blood vessel growth, and NPR reported FDA raised concerns about the potential to encourage cancer growth. If you have a cancer history, that is not a small footnote

NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR

Known copper allergies also preclude GHK-Cu use