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Small molecule programs remain high risk high reward Pfizers pullback from its own oral GLP-1 programs has highlighted a major scientific challenge: biased agonism can improve GI tolerability but does not eliminate hepatotoxicity risk

This approach can vary significantly from person to person, and it is essential to work closely with a clinician to determine the appropriate dosage

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Step therapy is another possible requirement for Ozempic coverage, depending on your insurance provider