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To harness the promising effects of GLP-1 for the development of a clinically useful drug, the short duration of action needed to be overcome

Targeted Screening : For patients with existing heart disease, close monitoring of cardiac function, muscle mass (through imaging or biomarkers) and other metabolic parameters has become increasingly important as the use of semaglutide and related drugs becomes more widespread

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Severe nausea, vomiting, and dizziness are less commonly reported with sublingual formulations, though they can still occur, especially at higher doses or when escalating too quickly