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A useful way to frame the difference: tretinoin is a top-down instruction that reprograms the epidermis, whereas GHK-Cu is a bottom-up supply of signal and cofactor that helps the dermis rebuild
This effect fades away with your morning routine
However, one potential side effect that requires monitoring is an elevated hematocrit level
The good news is that if you have a bottle of a primary amide and need to do some synthesis, you can convert it to a nitrile with a dehydration agent such as SOCl 2 , P 2 O 5, or POCl 3 : Amides to Aldehydes and Ketones The direct conversion of primary amides to aldehydes is challenging, so we can convert them to nitriles and reduce the nitrile to an aldehyde with DIBAL
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