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Ipamorelin often shows earlier changes in fat loss and recovery, but both can be maintained safely with ongoing guidance

Another phase 2 RCT studying semglutide 2.4 mg vs placebo in patients with compensated NASH cirrhosis did not show any statistically significant difference in NASH resolution or improvement in liver fibrosis between the groups

The retatrutide dose schedule still recommends starting at a conservative dose to assess tolerance of the glucagon component, even if you were on high-dose tirzepatide previously

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