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"Some experience this at starting doses," she notes, adding that she has many patients who have lost significant weight without ever escalating the dose
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FDA-approved uses Prozac has FDA approval for several conditions: Major depressive disorder (ages 8 and older) Obsessive-compulsive disorder (OCD, ages 7 and older) Panic disorder, with or without agoraphobia Bulimia nervosa Depressive episodes associated with Bipolar I disorder (used with olanzapine) Treatment-resistant depression (in combination with olanzapine) For OCD, clinical trials show that about 4060% of patients experience meaningful improvement in obsessive thoughts and compulsive behaviors at the right doses
When patients with concurrent prediabetes were treated with metformin, fibromyalgia symptoms improved in 42% of cases Mitochondrial dysfunction: Muscle biopsies from fibromyalgia patients reveal reduced mitochondrial enzyme activity and increased oxidative stress markers, potentially explaining the muscle pain and fatigue Neuroinflammation: Cerebrospinal fluid analysis shows improved levels of substance P, nerve growth factor, and glutamate in fibromyalgia patients, all markers of neuroinflammatory activity The metabolic connection is particularly compelling because it opens a new therapeutic avenue
