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10.3233/JAD-151098 73 RheinV.SongX.WiesnerA.IttnerL

General clinical guidance often includes: Dividing the dose (for example, morning and evening) to improve tolerance Taking NAC away from food if tolerated, as absorption may be better on an empty stomach Using NAC as part of a long-term strategy , since its benefits are related to ongoing antioxidant and anti-inflammatory support Some research protocols have used NAC cyclically (such as several days per week), while others use daily dosing

Since this mathematical model is quite complicated, it is useful to be clear why our model needs to include all of one carbon metabolism and not just the transsulfuration pathway

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