L., & le Roux, C
Oral Capsule Bioavailability Oral administration represents the most familiar and convenient delivery method, but faces unique challenges with peptide compounds: Absorption Rate : 30-50% typical bioavailability [3] Key Challenges : Peptides must survive stomach acid (pH 1.5-3.5) Digestive enzymes (pepsin, trypsin) break down protein structures First-pass metabolism in liver reduces available compound Absorption occurs primarily in small intestine Despite these obstacles, BPC-157's inherent stability in gastric acid gives it an advantage over many other peptides
And the progress doesnt always last
Post SM, Ma H, Ruvolo VR, Zhang X, Yasuhiro T, Tanaka K, Kozaki R, Yoshizawa T, Cortes J, DiNardo C, Konopleva M, Kornblau S, Khoury JD, Andreeff M , and Ruvolo PP