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Human translation will require careful evaluation of PK/PD, long-term safety, cardiovascular outcomes, tolerability, and body composition effects

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Depression is a strong determinant of poor QoL in patients with MS 10 , shares several features with fatigue , and both have a similar longitudinal course 28,29

The GH-IGF-1 cascade activated by this combination enhances muscle fiber repair and post-exercise recovery, making it highly relevant in regenerative and performance-related studies