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GHK-Cu stimulates angiogenesis primarily through upregulation of key growth factors including vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF/FGF-2), with research demonstrating that GHK-Cu at nanomolar concentrations increases VEGF expression in dermal fibroblasts and stimulates human umbilical vein endothelial cell (HUVEC) proliferation through enhanced VEGF and FGF-2 expression
This research gap reflects the challenging regulatory landscape for peptides and the lack of pharmaceutical industry interest in compounds that cannot be patented
Clinical evidence: absence There is no peer-reviewed randomized controlled trial of injectable or systemically administered GHK-Cu for any therapeutic indication
The supplement has to pass the liver before it reaches your bloodstream and the breakdown that occurs in the liver can cause it to leave behind most of the important parts
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