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6749 Tablets Janumet, 50 mg/1000 mg, are red, capsule-shaped, film-coated tablets with "577" debossed on one side

Within activated macrophages there are distinct changes in TCA cycle activity that lead to the accumulation of TCA cycle intermediates, particularly fumarate and itaconate

If these effects impact your daily life, try adopting lifestyle changes to help you return to your normal routines

GLP-1 medications have also been associated with: Worsening of diabetic retinopathy Exacerbation of age-related macular degeneration Optic nerve complications, including NAION These risks dont mean you should stop taking your medication, but they do show why its important to have an eye exam before starting and regular follow-up exams while on treatment