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2.1 Apoptosis Cell apoptosis is a genetically regulated autonomous cell death process, mainly mediated by the extrinsic death receptor pathway and the intrinsic mitochondrial pathway ( In COPD, substantial evidence supports a significant imbalance of apoptosis in airway and alveolar epithelium as well as alveolar macrophages

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To alleviate the gastrointestinal reaction of patients, at the beginning of the application of these drugs, clinical workers should know that the dosage should be gradually increased from a small dosage to enhance patients tolerance

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