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148 Similarly, downregulation of the PI3K/AKT pathway inhibits the proliferation, migration, and degranulation of eosinophils, basophils, and mast cells in mice
While the activation of T and B lymphocytes is primarily fueled by the engagement of their specific antigen receptors (T-cell receptors (TCRs) and B-cell receptors (BCRs)), a substantial body of evidence suggests that PRR activation, particularly that of TLRs, can either directly or synergistically interact with TCRs or BCRs to modulate lymphocyte responses
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