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The dual agonism also explains why tirzepatide produces different side effect profiles than semaglutide and other pure GLP-1 agonists
In chronic pain states, TRPV1 channels are upregulated in nociceptive neurons, which lowers stimulation thresholds and increases pain perception, as reported in hyperalgesia or allodynia 21
As a general principle applicable across weekly injectables: never take a double dose , and if you are unsure, contact your prescriber or trial team before injecting
Brain Res (2000) 878(1-2):1948
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