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The current data has shown good safety profile and lowering of hepatosteatosis
Physiological melanin hyperpigmentation is the result of increased melanin biosynthesis by melanocytes in the basal cell layer of the oral epithelium, but pathological melanin pigmentation may be the result of increased number of normal melanocytes or atypical melanocytes, of increased melanogenic activity of normal or atypical melanocytes, or of both
It reflects deeper biological processes hormones, inflammation, sun exposure, and internal balance
It contributes to blood glucose control by stimulating glucose-dependent insulin secretion, inhibiting glucagon release, delaying gastric emptying, and reducing appetite
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