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Lutrepulse [package insert]

1 Despite the availability of multiple treatments, a substantial proportion of patients either fail to achieve remission, particularly in cases of treatment-resistant depression (TRD) and late-life depression

The intravenous route was chosen for administration of the parenteral control since this would ensure greatest reproducibility of entry into the bloodstream, and would match more closely the time course of entry of peptide from the intestine, which is seen to be rapid