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Your body can produce it, and you also get it from food (especially red meat and dairy)
While under oxidative stress, the selective autophagy receptor and ubiquitin (Ub) sensor p62 binds to Keap1 and interferes with the Keap1NRF2 interaction when exposed to ferroptosisinducing agents [24], thus the NRF2 protein is stabilized and triggers downstream signal transduction to dampen the ferroptosis sensitivity of cells [25] [26, 27]
The identification of tubulins and protein disulfide-isomerase A3 across both cell lines suggests that X(PC) may promote cell death by targeting structural and apoptotic regulatory proteins, thereby mimicking broad caspase proteolysis activity during programmed cell death
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