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The study found that the effect of melatonin was not due to the melatonin receptors but rather acts in a receptor-independent manner to clear amyloid-beta plaque.[ref] In addition to clearing amyloid-beta plaque, another way that melatonin can protect against Alzheimers is through the reduction of ROS in the mitochondria in brain cells.[ref] This may be the key, rather than amyloid-beta clearance
Central Nervous System Drug Disposition: The Relationship between in Situ Brain Permeability and Brain Free Fraction
With a best-before period of 24 months, you can rely on its freshness, potency, and safety when stored below 25C
10.1038/nchembio.2238 54 KaushikM.YadavA.UpadhyayA.GuptaA.TiwariP.TripathiM.et al (2025)
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