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In terms of blood sugar control, these medications typically work better than oral diabetes medications

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Although DPP-4 inhibitors do not cross the BBB under normal conditions (the pharmacokinetic feature may prevent their repurposing use in neurodegenerative diseases), the permeability of BBB is increased in neurodegenerative diseases, so molecules otherwise unable to cross BBB could enter into CNS in these conditions (103)

Patients with specific genetic profilessuch as variants in or GIPR (rs1800437)may experience heightened or reduced digestive symptoms, enabling providers to personalize dose escalation schedules and formulation choices from the start