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In clinical trials, AOM tirzepatide has demonstrated greater weight loss efficacy compared with AOM semaglutide, suggesting that some patients transitioning therapies may experience different outcomes ( 11 , 12 )
From a patent perspective, the episode amplifies the pitfalls of incomplete lifecycle strategies
Activated CAFs secrete cytokines such as IL-6 and TGF-, remodel the ECM to create physical barriers, and promote immune evasion through paracrine signaling (34)
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