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Although the SVCT are the primary transporters for ascorbate, cells are also capable of ascorbate uptake via the activity of the facilitative glucose transporters, GLUT1, GLUT3, and GLUT4
That being said, different mechanisms may offer different side effect profiles, and its possible that future multi-agonists could yield improved tolerability profiles
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A rundown of some very serious complications from a readily available OTC therapy.
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