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In the SURMOUNT-5 trial (comparing these drugs at weight-loss doses), more people discontinued semaglutide due to side effects (5.6%) than tirzepatide (2.7%)
Oral Semaglutide for Type 2 diabetes was approved by the FDA in 2019 with an up to 14mg dose
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However, upon stopping the medication, they regained approximately two-thirds of the lost weight within a year, resulting in an overall 5.6 percent weight reduction from their starting weight
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