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[4] Based on animal research, it is thought that the increased methylmalonyl-CoA hydrolyzes to form methylmalonate (methylmalonic acid), a neurotoxic dicarboxylic acid, causing neurological deterioration

While some trials suggest a connection, more peer review is required to confirm whether oral vitamin B12 supplements or intramuscular injections can prevent fractures

Newborn infants of mothers who eat a plant-based diet and fail to supplement may develop deficiency much more rapidlyand with disastrous results

Patients with IBD have high levels of reactive oxygen species in their intestines, which contributes to damage caused by the disease