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Since mouse microbiome profiles often highly correlate with body weight and fat composition, this study was designed to test whether the cecal microbiomes of DIO mice treated with NNMTi and LD were comparable to the microbiomes of age-matched lean counterparts and distinct from microbiomes of DIO mice maintained on a high-fat Western diet (WD) or subjected to LD switch alone

Normally no, apart from an achy muscle at the injection site, which normally does not last for more than an hour or so

What if I do not like the result

When B12 is genuinely low, hair changes are well documented increased shedding, slower growth, reduced hair quality