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The authors analyzed differentially expressed genes and, upon further experimentation, involving HepG2 cells induced with palmitic acid, demonstrated that tirzepatide alleviates intrahepatic lipid accumulation in MASLD by downregulating CD36 and OBP2A, the key proteins involved in fatty acid uptake
Clinical trials highlight significant results, with participants losing an average of 15% of their body weight over 68 weeks
Lixisenatide is also a key ingredient in the diabetes drug Soliqua, which is available in the US
Those with heart or kidney disease should follow their healthcare provider's specific advice about fluid intake
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