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Subgroup analyses for patients pre-existing conditions As reported in a previously published article 26 , EASO identified several subgroups of patients with pre-existing comorbid conditions (Supplementary Table 3)

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The SUSTAIN clinical trial programme showed reduced risk of major adverse cardiovascular events in high-risk patients, although cardiovascular risk reduction is not a licensed indication in the UK

As an embodiment of the present invention, the reagent used for controlling the reaction pH in step (1) is a solution composed of a base, water and an organic solvent, the base is selected from an organic base or an inorganic base, the organic base is selected from any one of triethylamine, N-diisopropylethylamine, pyridine, piperidine and aniline, the inorganic base is selected from any one of alkali metal hydroxide and alkali metal carbonate, such as any one of sodium hydroxide, potassium hydroxide, sodium hydrogen phosphate and potassium hydrogen phosphate