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In the SURMOUNT-1 obesity trial, tirzepatide produced mean weight reductions of roughly 1521% depending on dose over 72 weeks ( Jastreboff et al., NEJM 2022
The peptide reaches peak plasma concentrations within 30 minutes and distributes to various tissues including liver, kidney, gastrointestinal tract, and injured tissues
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To compare the frequency difference between groups, the chi-squared test or Fischers exact test was used
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