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Published animal studies showed that epitalon administration to aged animals restored melatonin production toward youthful levels, normalized circadian rhythm amplitude, and was associated with extended lifespan in the treated groups

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This substantial reduction in endogenous Pure Copper peptide production directly correlates with the visible manifestations of skin aging, including decreased elasticity, diminished barrier function, increased transepidermal water loss, and reduced capacity for wound healing and tissue repair

Tartrate dehydrogenase catalyzes the stepwise oxidative decarboxylation of D-malate [PMID: 12356321] Laboratory literature summary: Tartrate dehydrogenase catalyzes the stepwise oxidative decarboxylation of D-malate with both NAD and thio-NAD