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Research focuses on how these changes sharply reduce its binding to the carrier proteins that normally limit insulin-like growth factor activity
The best binding poses for both substrates had a highly similar conformation to ()-catechin ( 12 ), with an RMSD of matched atoms of 0.51 for flavan-3,3,4-triol ( 4 ) and 0.54 for flavan-3-on-4-ol ( 7 )
For screened, appropriate candidates administered under medical oversight, IV therapy is generally well tolerated, with temporary effects like mild bruising at the site or a cool sensation during infusion
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