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MMA levels tell us how well the body uses B12
Mitochondrial metabolism is a key determinant of this polarization: M1 macrophages rely on glycolysis and have broken TCA cycles (as described), whereas M2 macrophages rely on intact OXPHOS and fatty acid oxidation, with high mitochondrial spare respiratory capacity ( etc
Some work reports effects on hair follicles and hair growth, largely in preclinical models and small cosmetic studies
265 YAP/TAZ also regulate immune evasion
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