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The reality is more nuanced and considerably more interesting

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Changes appeared within 11 to 28 days in mouse studies

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Salinas et al 27 The traditional treatment of vitamin B 12 deficiency is the intramuscular injection of cyanocobalamin, generally, 1 mg/d for 1 week, followed by 1 mg/wk for 1 month, and then 1 mg every 1 or2 months ad perpetuum

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Large-scale CQD synthesis is often hindered by batch-to-batch variability, impurity profiles, and contamination risks, emphasising the need for standardised, GMP-compliant synthesis protocols and robust quality control frameworks [178]

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