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Clin Endocrinol (Oxf) 2014;80(3):425-31

HRD1 inhibitors Pharmacological inhibition of HRD1, a negative regulator of NRF2 implicated in its ubiquitination and degradation, was tested in human liver tissues and in an animal model for the liver cirrhosis characterized by increased ER stress and ROS: LS-102 alleviated liver cirrhosis enhancing NRF2 signalling pathway [228]

It follows with increased melanin production that leads to hyperpigmentation and reduced effect of glutathione

Golan D, Staun-Ram E, Glass-Marmor L et al (2013) The influence of vitamin D supplementation on melatonin status in patients with multiple sclerosis