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Phase 3 trial results released in December 2025 showed participants lost an average of 28.7% of their body weight (about 71 pounds) over 68 weeks, the highest weight loss reported for any obesity medication to date

A: Usage should strictly follow the dosage guidelines as directed by a physician to maximize efficacy and minimize risk

Therefore, we are very excited about the results from SELECT showing that semaglutide 2.4 mg reduces the risk of cardiovascular events. Howard Weintraub, MD, a preventive cardiologist and clinical director of the Center for the Prevention of Cardiovascular Disease at NYU Langone Heart, worked as an investigator on the SELECT trial and is a consultant for Novo Nordisk

Shi K, Jiang W, Song L, Li X, Zhang C, Li L, et al