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PMID: 12 LincoffAMBrown-FrandsenKColhounHMDeanfieldJEmersonSSEsbjergSet al
PLoS ONE 3:e4871
By now, it has been established that the primary function of GLP-1 and GLP-1RA is to modulate brain regions that regulate appetite by influencing the release of neurotransmitters and peptides involved in hunger and energy balance
Patients who understand that the re-titration period is a necessary pharmacological bridge, not a step backward, are more likely to persist through the 12 weeks it takes to reach a therapeutic tirzepatide dose
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