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Jia L, Liao M, Mou A, Zheng Q, Yang W, Yu Z, et al
Evaluation: Body fat (DXA scanning) Lean mass Insulin sensitivity Energy expenditure What they found: The combination showed an additive effect on fat reduction vs monotherapy AOD-9604 partially protected lean mass during GLP-1-induced weight reduction Increased energy expenditure in combination (~3 % vs GLP-1 alone) No new safety signals Why it matters: It validates the concept of combination , the idea that AOD-9604 may not work on its own, but can add value in combination with incretin agonists
As discussed by Gale and Foy (see page 939, in this issue) the interplay between HCV and innate cellular antiviral pathways may be a major intracellular determinant of HCV tropism
10.1007/s11695-017-2980-3 6
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