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One of the standout findings from Phase 2 was the substantial weight reduction achieved by participants
The cardiovascular benefits appear strongest in patients who achieve and maintain 10% or greater body weight reduction, making long-term adherence to therapy a critical success factor
Note that the norleucine substitution at position 4 has already removed the methionine thioether, so residual oxidation risk in this analogue is concentrated at tryptophan
Dietary habits, eating patterns, and the rate of dose escalation can all influence the severity of bloating symptoms
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