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While the regulation of MTHFR activity is closely controlled by SAM at C-terminal regulatory domain, more studies indicated that the human MTHFR enzyme activity is also regulated by multiple phosphorylated sites on a serine-rich N-terminal extension region 20

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Wu Y, Zhao Y, Yang H-z, Wang Y-j, Chen Y

Finally, remember that the most reliable half-life and stability data are always those published in peer-reviewed pharmacokinetic studies for the specific peptide, formulation, and species of interest