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doi: 10.3390/v13061062 170 GnzlPBauerKHainzlEMattUDillingerBMahrBet al
Across preclinical studies, Epitalon has shown: Telomerase activation and telomere extension: Via TRAP assays and fibroblast lifespan extension beyond the Hayflick limit Epigenetic remodeling: Reversal of chromatin aging, histone modulation, and gene promoter binding Redox homeostasis: Increased antioxidant enzymes (SOD, NQO1, catalase) and reduced ROS, lipid peroxidation, and DNA damage Circadian restoration: Upregulation of AANAT/pCREB, normalized melatonin and cortisol rhythms, and clock gene modulation in humans Cancer risk reduction: Reduced tumor multiplicity and delayed onset in HER-2/neu and colon cancer models
Paired-end FASTQ files were then run through the DADA2 pipeline (v1.8) to generate an amplicon sequence variant (ASV) table and assign taxonomy
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