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Butler PC, Elashoff M, Elashoff R, et al
Neurology 49(6):16211630 Borasio GD, Robberecht W, Leigh PN, Emile J, Guiloff RJ, Jerusalem F, Silani V, Vos PE, Wokke JH, Dobbins T (1998) A placebo-controlled trial of insulin-like growth factor-i in amyotrophic lateral sclerosis
These gastrointestinal symptoms are usually mild to moderate and often decrease as the treatment continues
Baseline body weight, insulin resistance severity, and beta-cell function all contribute to treatment response
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